[학력]
1992. 3 ~ 1996. 2 서울대학교 식품공학과, 학사
1996. 3 ~ 1998. 2 서울대학교 식품공학과, 석사
1998. 3 ~ 2002. 8 서울대학교 식품공학과, 박사
[경력]
2002. 9 ~ 2005. 3 서울대학교 농업생물신소재연구소, 박사후연구원
2005. 4 ~ 2007. 2 Burnham Institute for Medical Research (USA), Postdoctoral associate
2007. 3 ~ 현재 부산대학교 식품영양학과, 교수
* 국외학술지 논문
1. Kim, J.W., Kim, Y.H., Lee, H.S., Yang, S.J., Kim, Y.W., Lee, M.H., Kim, J.W., Seo, N.S., Park, C.S., Park, K.H. 2007. Molecular cloning and biochemical characterization of the first archaeal maltogenic amylase from the hyperthermophilic archaeon Thermoplasma volcanium GSS1. Biochim. Biophys. Acta., In press.
2. Wang, P., Lee, H., Fukuda, M., and Seeberger P.H. 2007. One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun., In press.
3. Lee, M.H., Yang, S.J., Kim, J.W., Lee, H.S., Kim, J.W., and Park, K.H. 2007. Characterization of a thermostable cyclomaltodextrin glucanotransferase from Pyrococcus furiosus DSM3638. Extremophiles, In press.
4. Kobayashi, M, Lee, H., Schaffer, L., Gilmartin, T.J., Head, S.R., Takaishi, S., Wang, T.C., Nakayama, J., and Fukuda, M. 2007. A distinctive set of genes is up-regulated during the inflammation-carcinoma sequence in mouse stomach infected by Helicobacter felis. J. Histochem. Cytochem. 55(3): 263-274.
5. Fukuda, M., Kawakubo, M., Ito, Y., Kobayashi, M., Lee, H., and Nakayama, J. 2006. Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Methods Enzymol. 415: 164-179.
6. Lee, H., Kobayashi, M., Wang, P., Nakayama, J., Seeberger, P.H., and Fukuda, M. Expression cloning of cholesterol α-glucosyltransferase, a unique enzyme that can ce inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 349: 1235-1241.
7. Yang, S.J., Lee, H.S., Kim, J.W., Lee, M.H., Auh, J.H., Lee, B.H., and Park, K.H. 2006. Enzymatic preparation of maltohexaose, maltoheptaose, and maltooctaose by the preferential cyclomaltooligosaccharide (cyclodextrin) ring-opening reaction of PFTA. Carbohydr. Res. 341(3): 420-424.
8. Lee, H.S., Kim, J.S., Shim, K, Kim, J.W., Inouye, K., Oneda, H., Kim, Y.W., Cheong, K.A., Cha, H., Woo, E.J., Auh, J.H., Lee, S.J., Kim, J.W., and Park, K.H. 2006. Dissociation/association properties of a dodecameric cyclomaltodextrinase: effects of pH and salt concentration on the oligomeric state. FEBS J. 273: 109-121.
9. Lee, H.S., Kim, J.S., Shim, K.H., Kim, J.W., Park, C.S., and Park, K.H. 2005. Quaternary structure and enzymatic properties of cyclomaltodextrinase from alkalophilic Bacillus sp. I-5. Biologia Bratislava. 60, Suppl.16: 73-77.
10. Roh, H.J., Kang, S.C., Lee, H.S., Kim, D.K., Byun, S.B., Lee, S.J., and Park, K.H. 2005. Transglycosylation of tagatose with maltotriose by Bacillus stearothermophilus maltogenic amylase (BSMA). Tetrahedron: Asymmetry 16(1): 77-82.
11. Dan, L., Park, S.H., Shim, J.H., Lee, H.S., Tang, S.Y., Park, C.S., and Park, K.H. 2004. In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase. Carbohydr. Res. 339: 2789-2797.
12. Yang, S.J., Lee, H.S., Park, C.S., Kim, Y.R., Moon, T.W., and Park, K.H. 2004. Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archeon Pyrococcus furiosus reveals its novel catalytic properties as both an α-amylase and a cyclodextrin-hydrolyzing enzyme. Appl. Environ. Microbiol. 70(10): 5988-5995.
13. Kim, M.S., Park, J.T., Kim, Y.W., Lee, H.S., Nyawira, R., Shin, H.S., Park, C.S., Yoo, S.H., Kim, Y.R., Moon, T.W., and Park, K.H. 2004. Properties of a novel thermostable glucoamylase from the hyperthermophilic archaeon Sulfolobus solfataricus in relation to starch processing. Appl. Environ. Microbiol. 70(7): 3933-3940.
14. Kimura, A., Lee, J.H., Lee, I.S., Lee, H.S., Park, K.H., Chiba, S., and Kim, D. 2004. Two potent competitive inhibitors discriminating α-glucosidase family I from family II. Carbohydr. Res. 339: 1035-1040.
15. Baek, J.S., Kim, M.J., Cha, H., Lee, H.S., Li, D., Kim, J.W., Kim, Y.R., Moon, T.W., and Park, K.H. 2003. Enhanced transglycosylation activity of Thermus maltogenic amylase in acetone solution. Food Sci. Biotechnol. 12(6): 639-643.
16. Lee, H.Y., Kim, M.J., Baek, J.S., Lee, H.S., Cha, H.J., Lee, S.B., Moon, T.W., Seo, E.S., Kim, D., Park, C.S., and Park, K.H. 2003. Preparation and characterization of maltosyl-sucrose isomers produced by transglycosylation of maltogenic amylase from Bacillus stearothermophilus. J. Mol. Catal. B:Enzym. 26: 293-305.
17. Yoon, J.W., Jeon, E.J., Jung, I.H., Min, M.J., Lee, H.Y., Kim, M.J., Baek, J.S., Lee, H.S., Park, C.S., Park, K.H., and Moon, T.W. 2003. Maltosyl-erythritol, a major transglycosylation product of erythritol by Bacillus stearothermophilus maltogenic amylase. Biosci. Biotechnol. Biochem. 67(3): 525-531.
18. Park, K.H., Lee, H.S., Kim, T.J., Cheong, K.A., Nguyen, V.D., Min, M.J., Cho, H.Y., Kim, Y.W., Park, C.S., Oh, B.H., and Kim, J.W. 2002. N- and C-terminal region mediated oligomerization of the cyclodextrin-/pulluan degrading enzymes. Biologia Bratislava. 57,Suppl.11: 87-92.
19. Kim, M.J., Lee, H.S., Cho, J.S., Kim, T.J., Moon, T.W., Oh, S.T., Kim, J.W., Oh, B.H., and Park,K.H. 2002. Preparation and characterization of α-D-glucopyranosyl-α-acarviosinyl-D-glucopyranose, a novel inhibitor specific for maltose-producing amylase. Biochemistry 41(29): 9099-9108.
20. Lee, H.S., Kim, M.S., Cho, H.S., Kim, J.I., Kim, T.J., Choi, J.H., Park, C., Lee, H.S., Oh, B.H., and Park, K.H. 2002. Cyclomaltodextrinase, neopullulanase, and maltogenic amylase are nearly indistinguishable from each other. J. Biol. Chem. 277(24): 21891-21897.
21. Kim, T.J., Nguyen, V.D., Lee, H.S., Kim, M.J., Cho, H.Y., Kim, Y.W., Moon, T.W., Park, C.S., Kim, J.W., Oh, B.H., Lee, S.B., Svensson, B., and Park, K.H. 2001. Modulation of the Multisubstrate Specificity of Thermus Maltogenic Amylase by Truncation of the N-Terminal Domain and by a Salt-Induced Shift of the Monomer/Dimer Equilibrium. Biochemistry 40(47): 14182-14190.
22. Cho, H.Y., Kim, Y.W., Kim, T.J., Lee, H.S., Kim, D.Y., Kim, J.W., Lee, Y.W., Lee, S.B., and Park, K.H. 2000. Molecular characterization of a dimer intracellular maltogenic amylase of Bacillus subtilis SUH4-2. Biochem. Biophys. Acta. 1478: 333-340.
23. Kim, M.J., Park, W.S., Lee, H.S., Kim, T.J., Shin, J.H., Yoo, S.H., Cheong, T.K., Ruy, S.R., Kim, J.C., Kim, J.W., Moon, T.W., Robyt, J.F. and Park, K.H. 2000. Kinetics and inhibition of cyclomaltodextrinase from alkalophilic Bacillus sp. I-5. Arch. Biochem. Biophys. 373(1): 110-115.
24. Kim, M.J., Lee, S.B., Lee, H.S., Lee, S.Y., Baek, J.S., Kim, D.M., Moon, T.W., Robyt, J.F. and Park, K.H. 1999. Comparative study of the inhibition of α-glucoside, α-amylase and cyclomaltodextrin glucanotransferase by acarbose, isoacarbose and acarviosine-glucose. Arch. Biochem. Biophys. 371(2): 277-283.
25. Kim, J.S., Cha, S.S., Kim, H.J., Kim, T.J., Ha, N.C., Oh, S.T., Cho, H.S., Cho, M.J., Kim, M.J., Lee, H.S., Kim, J.W., Choi, K.Y., Park, K.H., and Oh, B.H. 1999. Crystal Structure of a Maltogenic Amylase Provides Insights into a Catalytic Versatility. J. Biol. Chem. 274(37): 26279-26286.
26. Park, K.H., Kim, M.J., Lee, H.S., Han, N.S., Kim, D., and Robyt, J.F. 1998. Transglycosylation reactions of Bacillus stearothermophilus maltogenic amylase with acarbose and various acceptors. Carbohydr. Res. 313: 235-246.
27. Cho, M.J., Cha, S.S., Park, J.H., Cha, H.J., Lee, H.S., Park, K.H. and Oh, B.H. 1998. Preliminary X-ray Crystallographic Analysis of a Novel Maltogenic Amylase From Bacillus stearothermophilus ET1. Acta Crystallogr. D Biol. Crystallogr. 54: 416-418.
28. Cha, H.J., Yoon, H.G., Kim, Y.W., Lee, H.S., Kim, J.W., Kwon, K., Oh, B.H., and Park, K.H. 1998. Molecular and enzymatic characterization of a maltogenic amylase that hydrolyzes and transglycosylates acarbose, Eur. J. Biochem. 253(1):251-262.